NeuroAxis — Nerve Health Support

The natural, bioactive form of alpha lipoic acid — the form the body actually produces and uses in key mitochondrial enzyme complexes. R-ALA may help support healthy oxidative balance and nerve energy metabolism.

Why it's in NeuroAxis: R-ALA serves as both a mitochondrial cofactor and a lipid/water-phase antioxidant, and can help regenerate Vitamins C, E, glutathione, and CoQ10. The 600 mg dose matches the canonical amount used in published neuropathy research and is the most studied single daily dose for this ingredient.

A stable, orally bioavailable cysteine precursor that supports glutathione synthesis — the body's primary intracellular antioxidant. NAC may help support mitochondrial redox balance and healthy cellular defense in neural tissues.

Why it's in NeuroAxis: NAC directly feeds the glutathione synthesis pathway and helps replenish mitochondrial glutathione — critical for limiting oxidative damage from the respiratory chain. At 900 mg, it sits in the mid-range of commonly studied oral doses and complements R-ALA's antioxidant activity.

An acetylated form of L-carnitine that crosses the blood-brain barrier more readily than plain carnitine. ALCAR supports mitochondrial fatty acid transport and acetyl-CoA availability — contributing to energy metabolism in nerve and brain tissue.

Why it's in NeuroAxis: ALCAR contributes both to the "carnitine shuttle" that moves fatty acids into mitochondria for energy production, and provides acetyl groups used in membrane lipid synthesis — including those relevant to myelin. The 600 mg dose supports mitochondrial function as part of the broader energy stack without reaching the gram-level doses used in standalone neuropathy trials.

A fat-soluble Vitamin B1 derivative with significantly higher bioavailability than standard thiamine. Benfotiamine supports thiamine-dependent carbon flux — the metabolic pathways that peripheral nerves rely on for healthy energy utilization.

Why it's in NeuroAxis: By supporting transketolase activity, benfotiamine helps redirect glucose metabolites away from pathways associated with metabolic stress in peripheral nerves. The 300 mg dose aligns with the lower end of clinical trial ranges and pairs with methylcobalamin and B6 to form the methylation and myelin support layer of this formula.

A standardized extract providing approximately 475 mg of curcuminoids per serving — far more potent than culinary turmeric. Curcumin modulates NF-κB and activates Nrf2 antioxidant pathways, supporting healthy inflammatory balance in the tissue environment surrounding peripheral nerves.

Why it's in NeuroAxis: Curcumin addresses inflammation at the signaling level — modulating cytokines and microglial activation pathways — while also contributing to oxidative defense. Its bioavailability from a standard extract is significantly enhanced by the BioPerine® in this formula, which research suggests can increase curcumin absorption meaningfully.

An essential electron carrier in the mitochondrial respiratory chain, supporting ATP synthesis and acting as a lipid-phase antioxidant in cell membranes. CoQ10 levels may decline with age and with certain medications including statins.

Why it's in NeuroAxis: CoQ10 plays a non-substitutable role in the electron transport chain and provides membrane-level antioxidant protection alongside R-ALA, NAC, and ALCAR. The 150 mg dose sits within the lower-to-mid range used in cardiovascular and metabolic research, appropriate for a comprehensive multi-ingredient formula rather than standalone high-dose therapy.

The active coenzyme form of Vitamin B12, used directly by cells without requiring conversion. Methylcobalamin serves as the cofactor for methionine synthase — the enzyme that remethylates homocysteine to methionine, central to healthy one-carbon metabolism and myelin-relevant phospholipid synthesis.

Why it's in NeuroAxis: Methylcobalamin is the primary methylation and myelin-support anchor in this formula, pairing directly with Benfotiamine and B6. The 2,000 mcg dose is modestly above typical neuropathy trial ranges, providing a meaningful buffer for passive absorption — particularly relevant for older adults or those with subclinical absorption challenges.

A systemic proteolytic enzyme that may support healthy inflammatory balance and normal tissue response to physical stress. Serrapeptase works by breaking down fibrin and inflammatory proteins in tissue environments — potentially relevant to the perineural space surrounding nerves.

Why it's in NeuroAxis: Unlike antioxidants that work at the molecular level, serrapeptase acts on the physical tissue environment — breaking down fibrinous debris and supporting normal drainage of inflammatory material. This "terrain-level" activity complements the signaling-level effects of curcumin. The 40,000 SU dose is consistent with commercial systemic enzyme preparations used in anti-inflammatory applications.

A proteolytic enzyme complex derived from pineapple stem, used for its anti-edematous and inflammation-modulating properties. Bromelain targets cytokines, prostaglandins, and tissue swelling — supporting a healthier tissue environment around nerve structures. Dr. Fitzmaurice has published research on bromelain's relevance to neuropathic pain.

Why it's in NeuroAxis: Bromelain acts on inflammatory mediators including COX-2, NF-κB, and pro-inflammatory cytokines, complementing serrapeptase's fibrinolytic action and curcumin's signaling-level effects. Together these three form a comprehensive tissue environment layer. The 600 GDU dose reflects systemic enzyme-level activity consistent with anti-inflammatory applications.

A key cofactor for neurotransmitter synthesis, amino acid metabolism, and the transsulfuration pathway — which converts homocysteine to cysteine and feeds glutathione production. Vitamin B6 works in direct partnership with methylcobalamin in homocysteine metabolism.

Why it's in NeuroAxis: B6 completes the homocysteine-handling triad alongside methylcobalamin and benfotiamine, addressing both the remethylation and transsulfuration routes. The 10 mg dose is several-fold above the RDA while remaining well within established safety limits — intentionally selected to support cofactor availability without approaching ranges associated with excessive B6 intake.

The natural, sun-derived form of Vitamin D, converted in the body to a hormone-like compound that acts on receptors found in nerve tissue, immune cells, and glial cells. Vitamin D3 may help support neuroimmune balance and the biological environment relevant to myelin maintenance.

Why it's in NeuroAxis: Vitamin D3 is included as a neuroimmune context ingredient — supporting the broader biological milieu in which nerve health operates, including immune modulation and myelin-relevant pathways identified in experimental models. The 800 IU dose provides meaningful nutritional support at the upper end of traditional maintenance ranges, comfortably within established safety limits.

A patented black pepper extract standardized to ≥95% piperine, included specifically to enhance the absorption of key co-formulated nutrients — particularly curcumin, CoQ10, and Vitamin D3. BioPerine® works by inhibiting intestinal CYP3A4 and P-glycoprotein, reducing first-pass metabolism of co-administered compounds.

Why it's in NeuroAxis: BioPerine® functions as a precision bioavailability multiplier for the entire formula — ensuring that poorly absorbed ingredients like curcumin actually reach systemic circulation at meaningful levels. Without it, a significant portion of the curcumin dose would be lost in first-pass metabolism. At 10 mg it sits at the top of the clinically studied range for absorption enhancement.